Should you always write what you know?

Not always, says author Beth Erickson, who suggests that you try new markets, write whatever strikes your fancy, and if it makes you more comfortable, use a pen name when experimenting with subjects outside your primary focus.

I recommend an 80/20 ratio: 80% of your writing projects should be in familiar areas where you have skill, expertise, and knowledge. Doing so ensures you are profitable on a per-hour basis.

But 20% of your writing projects should be in new products, new markets, new venues, or new forms. This keeps you fresh and prevents you from getting bored.

I am probably more 90/10. But I would never be 100/0, for the aforementioned risk of boredom and getting stale.
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For instance, a writer whose work I admire, TB, writes exclusively about the silver market.

Yes, he’s enviably efficient, productive, good, and respected. But if I wrote about nothing but one subject 24/7, I would go out of my skull.

Source: Writing Etc., 3/12/14